NanoGhost - technology - heroimage
NanoGhst-headline shape

The Technology

NanoGhost- are nanovesicles derived from the ce

NGs are nanovesicles derived from the cell membranes of allogeneic Mesenchymal Stem Cells (MSCs).


Using the NanoGhost technology, MSCs are emptied from their intracellular content and the cell membrane is downsized to the nanomolar range while its architecture and characteristics are retained.

 

NGs can be loaded with different therapeutics, ranging from small molecule drugs to proteins and nucleic acids.

Mesenchymal Stem Cells w/ Natural Tropism to Cancer

NanoGhost- Mesenchymal Stem Cells w/ Natural Tropism to Cancer
NanoGhost- Cytoplasm Removed

Cytoplasm

Removed

Ghosts retaining source cell membranes and targeting capabilites

NanoGhost-Ghosts retaining source cell membranes and targeting capabilites
NanoGhost- payload

Payload

Introduced

Drug loaded Nano-Ghosts w/ trageting capability

Drug loaded Nano-Ghosts w/ trageting capability
NanoGhost- Drug loaded Nano-Ghosts w/ trageting capability

Micro Scale

Nano Scale

NanoGhost Platform Characteristics

NanoGhost Platform Characteristics

NanoGhost- icon Targeted & Selective

Targeted & Selective

NGs selectively target tumors, sites of inflammation and injury while demonstrating fast clearance from normal tissues

NanoGhst icon- Versatile

Versatile

NGs can be loaded with

various therapeutic cargos (small molecules, nucleic acids, proteins, plasmids) with wide payload

size range

NanoGhst icon- Crosses Physiological Barriers

Crosses Physiological Barriers

NGs cross the BBB
(GBM, MS) and tumor barriers (Pancreatic Cancer)

NanoGhst- Broad Applicability

Broad Applicability

PoC demonstrated in
oncological, neurodegenerative,
and autoimmune models

NanoGhost

Non-Immunogenic

NGs retain MSCs

allogeneic tolerability

NanoGhost- Off the shelf

Off the shelf

NGs are “off-the-shelf”

nanoparticles manufactured using controlled scalable process

NanoGhost Platform Versatility

Oncology

Loaded NGs for Targeted Drug & Gene Delivery

Solid Tumors including Pancreatic, GBM and NSCLC

Immune Oncology, other

Engineered NGs

Armed NGs Ectopically Expressing Protein of Interest (PD-1, T cell

Death Receptor or Other)

Inflammatory & Autoimmune

Immunomodulatory
NGs (cargo optional)

MS, OA, MI

Diagnostics

NGs Loaded with

Diagnostic Labels

Disease Imaging

NanoGhost- NGs mediated delivery of Anti miR221X1.j

Nucleus

NGs

Actin

NGs mediated delivery of Anti miR221 to target cells. NGs were labeled with DiD lipophilic dye (green), nuclei with DAPI (blue) and actin network with Phalloidin (purple).

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