The Technology
NGs are nanovesicles derived from the cell membranes of allogeneic Mesenchymal Stem Cells (MSCs).
Using the NanoGhost technology, MSCs are emptied from their intracellular content and the cell membrane is downsized to the nanomolar range while its architecture and characteristics are retained.
NGs can be loaded with different therapeutics, ranging from small molecule drugs to proteins and nucleic acids.
Mesenchymal Stem Cells w/ Natural Tropism to Cancer
Cytoplasm
Removed
Ghosts retaining source cell membranes and targeting capabilites
Payload
Introduced
Drug loaded Nano-Ghosts w/ trageting capability
Micro Scale
Nano Scale
NanoGhost Platform Characteristics
Targeted & Selective
NGs selectively target tumors, sites of inflammation and injury while demonstrating fast clearance from normal tissues
Versatile
NGs can be loaded with
various therapeutic cargos (small molecules, nucleic acids, proteins, plasmids) with wide payload
size range
Crosses Physiological Barriers
NGs cross the BBB
(GBM, MS) and tumor barriers (Pancreatic Cancer)
Broad Applicability
PoC demonstrated in
oncological, neurodegenerative,
and autoimmune models
Non-Immunogenic
NGs retain MSCs
allogeneic tolerability
Off the shelf
NGs are “off-the-shelf”
nanoparticles manufactured using controlled scalable process
NanoGhost Platform Versatility
Oncology
Loaded NGs for Targeted Drug & Gene Delivery
Solid Tumors including Pancreatic, GBM and NSCLC
Immune Oncology, other
Engineered NGs
Armed NGs Ectopically Expressing Protein of Interest (PD-1, T cell
Death Receptor or Other)
Inflammatory & Autoimmune
Immunomodulatory
NGs (cargo optional)
MS, OA, MI
Diagnostics
NGs Loaded with
Diagnostic Labels
Disease Imaging
Nucleus
NGs
Actin
NGs mediated delivery of Anti miR221 to target cells. NGs were labeled with DiD lipophilic dye (green), nuclei with DAPI (blue) and actin network with Phalloidin (purple).