NGs are nanovesicles derived from the cell membranes of allogeneic Mesenchymal Stem Cells (MSCs).
Using the NanoGhost technology, MSCs are emptied from their intracellular content and the cell membrane is downsized to the nanomolar range while its architecture and characteristics are retained.
NGs can be loaded with different therapeutics, ranging from small molecule drugs to proteins and nucleic acids.
Mesenchymal Stem Cells w/ Natural Tropism to Cancer
Ghosts retaining source cell membranes and targeting capabilites
Drug loaded Nano-Ghosts w/ trageting capability
NanoGhost Platform Characteristics
Targeted & Selective
NGs selectively target tumors, sites of inflammation and injury while demonstrating fast clearance from normal tissues
NGs can be loaded with
various therapeutic cargos (small molecules, nucleic acids, proteins, plasmids) with wide payload
Crosses Physiological Barriers
NGs cross the BBB
(GBM, MS) and tumor barriers (Pancreatic Cancer)
PoC demonstrated in
and autoimmune models
NGs retain MSCs
Off the shelf
NGs are “off-the-shelf”
nanoparticles manufactured using controlled scalable process
NanoGhost Platform Versatility
Loaded NGs for Targeted Drug & Gene Delivery
Solid Tumors including Pancreatic, GBM and NSCLC
Immune Oncology, other
Armed NGs Ectopically Expressing Protein of Interest (PD-1, T cell
Death Receptor or Other)
Inflammatory & Autoimmune
NGs (cargo optional)
MS, OA, MI
NGs Loaded with
NGs mediated delivery of Anti miR221 to target cells. NGs were labeled with DiD lipophilic dye (green), nuclei with DAPI (blue) and actin network with Phalloidin (purple).